KMID : 1225720150070020195
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Allergy, Asthma & Immunology Research : AAIR 2015 Volume.7 No. 2 p.195 ~ p.198
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An IgE-Mediated Allergic Reaction Caused by Mulberry Fruit
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Choi Jong-Hyun
Sim Jae-Kyoem Oh Jee-Youn Hur Gyu-Young Min Kyung-Hoon Lee Sung-Yong Shim Jae-Jeong Kang Kyung-Ho
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Abstract
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Mulberry (Morus spp.) is a widespread deciduous tree and its fruit is commonly eaten in Korea and eastern Asia. Some reports demonstrate that mulberry fruit is a food allergen in the Mediterranean area. However, there has been no report of systemic allergic reactions after ingesting mulberry fruit in Korea. An 18-year-old boy with a mulberry fruit allergy visited our allergy clinic. He had experienced generalized urticaria, chest tightness, breathing difficulty, and abdominal cramping after ingesting mulberry fruit. The patient had a positive skin reaction to mulberry fruit extract (mean wheal size, 5 mm). We performed an ELISA to detect specific IgE antibody (Ab) to mulberry fruit extract in the patient¡¯s serum compared to those of non-atopic healthy controls and birch-sensitized individuals. Specific IgE Ab to mulberry fruit extract was detected in the patient¡¯s serum, as compared to non-atopic healthy controls. Another subject, who was strongly sensitized to birch pollen, also had a positive serum-specific IgE Ab to mulberry fruit. We performed IgE immunoblot analysis using the patient¡¯s and the other subject¡¯s sera, who had serum-specific IgE to mulberry fruit, to identify the IgE-binding component. An identical IgE-binding component to mulberry extract was detected in the two subjects at around 17 kDa, and which might be PR 10 of Bet v 1. In conclusion, mulberry fruit could induce a systemic allergic reaction through an IgE-mediated mechanism, and cross-reactivity might occur between mulberry fruit and birch pollen.
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KEYWORD
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Mulberry, allergen, food allergy, IgE
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